Results

CRUZIVAX publication

Lee S., Nasr S., Rasheed S., Liu Y., Hartwig O., Kaya C., Boese A., Koch M., Herrmann J., Müller R., Loretz B., Buhler E., ... , Hirsch A.K.H., Lehr C.M. (2022)
Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape
J.Control.Release, 353

This study aims to inform the development of two vaccines for the prevention and treatment of Trypanosoma cruzi infection, and guide their pre-clinical phase up to clinical phase I. The three main objectives are: 1) to explore patients’ and policy makers’ preferences on the candidate vaccines in Argentina and Spain; 2) to investigate health-related quality of life of patients affected by Chagas disease; and 3) to assess the potential health provider savings associated with the vaccines, in terms of resource use and health care costs.

When available, further results will be made public here and on our Zenodo Community.
https://zenodo.org/communities/cruzivax/